Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.
Identifieur interne : 000438 ( Main/Exploration ); précédent : 000437; suivant : 000439Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.
Auteurs : Jun-Ichi Inaba [États-Unis] ; Peter D. Nagy [États-Unis]Source :
- Virology [ 1096-0341 ] ; 2018.
Descripteurs français
- KwdFr :
- ARN viral (biosynthèse), Adénosine triphosphate (métabolisme), Complexe-1 cible mécanistique de la rapamycine (antagonistes et inhibiteurs), Complexe-1 cible mécanistique de la rapamycine (métabolisme), Facteurs de transcription (antagonistes et inhibiteurs), Facteurs de transcription (métabolisme), Glycolyse (MeSH), Interactions hôte-pathogène (MeSH), Morpholines (pharmacologie), Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs), Protéines de Saccharomyces cerevisiae (métabolisme), RNA replicase (métabolisme), Ribonucléotides (biosynthèse), Réplication virale (MeSH), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Saccharomyces cerevisiae (virologie), Sirolimus (pharmacologie), Tabac (effets des médicaments et des substances chimiques), Tabac (métabolisme), Tabac (virologie), Tombusvirus (génétique), Tombusvirus (physiologie).
- MESH :
- antagonistes et inhibiteurs : Complexe-1 cible mécanistique de la rapamycine, Facteurs de transcription, Protéines de Saccharomyces cerevisiae.
- biosynthèse : ARN viral, Ribonucléotides.
- effets des médicaments et des substances chimiques : Saccharomyces cerevisiae, Tabac.
- génétique : Saccharomyces cerevisiae, Tombusvirus.
- métabolisme : Adénosine triphosphate, Complexe-1 cible mécanistique de la rapamycine, Facteurs de transcription, Protéines de Saccharomyces cerevisiae, RNA replicase, Saccharomyces cerevisiae, Tabac.
- pharmacologie : Morpholines, Sirolimus.
- physiologie : Tombusvirus.
- virologie : Saccharomyces cerevisiae, Tabac.
- Glycolyse, Interactions hôte-pathogène, Réplication virale.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Glycolysis (MeSH), Host-Pathogen Interactions (MeSH), Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors), Mechanistic Target of Rapamycin Complex 1 (metabolism), Morpholines (pharmacology), RNA Replicase (metabolism), RNA, Viral (biosynthesis), Ribonucleotides (biosynthesis), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae (virology), Saccharomyces cerevisiae Proteins (antagonists & inhibitors), Saccharomyces cerevisiae Proteins (metabolism), Sirolimus (pharmacology), Tobacco (drug effects), Tobacco (metabolism), Tobacco (virology), Tombusvirus (genetics), Tombusvirus (physiology), Transcription Factors (antagonists & inhibitors), Transcription Factors (metabolism), Virus Replication (MeSH).
- MESH :
- chemical , antagonists & inhibitors : Mechanistic Target of Rapamycin Complex 1, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , biosynthesis : RNA, Viral, Ribonucleotides.
- chemical , metabolism : Adenosine Triphosphate, Mechanistic Target of Rapamycin Complex 1, RNA Replicase, Saccharomyces cerevisiae Proteins, Transcription Factors.
- chemical , pharmacology : Morpholines, Sirolimus.
- drug effects : Saccharomyces cerevisiae, Tobacco.
- genetics : Saccharomyces cerevisiae, Tombusvirus.
- metabolism : Saccharomyces cerevisiae, Tobacco.
- physiology : Tombusvirus.
- virology : Saccharomyces cerevisiae, Tobacco.
- Glycolysis, Host-Pathogen Interactions, Virus Replication.
Abstract
Similar to other (+)RNA viruses, tomato bushy stunt virus (TBSV) utilizes metabolites, lipids, membranes, and co-opted host factors during replication. The coordination of cell metabolism and growth with environmental cues is performed by the target of rapamycin (TOR) kinase in eukaryotic cells. In this paper, we find that TBSV replication partially inhibits TOR activity, likely due to recruitment of glycolytic enzymes to the viral replication compartment, which results in reduced ATP levels in the cytosol. Complete inhibition of TOR activity with rapamycin in yeast or AZD8055 inhibitor in plants reduces tombusvirus replication. We find that high glucose concentration, which stimulates TOR activity, enhanced tombusvirus replication in yeast. Depletion of yeast Sch9 or plant S6K1 kinase, a downstream effector of TOR, also inhibited tombusvirus replication in yeast and plant or the assembly of the viral replicase in vitro. Altogether, the TOR pathway is crucial for TBSV to replicate efficiently in hosts.
DOI: 10.1016/j.virol.2018.04.010
PubMed: 29734044
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.</title><author><name sortKey="Inaba, Jun Ichi" sort="Inaba, Jun Ichi" uniqKey="Inaba J" first="Jun-Ichi" last="Inaba">Jun-Ichi Inaba</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Nagy, Peter D" sort="Nagy, Peter D" uniqKey="Nagy P" first="Peter D" last="Nagy">Peter D. Nagy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, United States. Electronic address: pdnagy2@uky.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29734044</idno><idno type="pmid">29734044</idno><idno type="doi">10.1016/j.virol.2018.04.010</idno><idno type="wicri:Area/Main/Corpus">000559</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000559</idno><idno type="wicri:Area/Main/Curation">000559</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000559</idno><idno type="wicri:Area/Main/Exploration">000559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.</title><author><name sortKey="Inaba, Jun Ichi" sort="Inaba, Jun Ichi" uniqKey="Inaba J" first="Jun-Ichi" last="Inaba">Jun-Ichi Inaba</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Nagy, Peter D" sort="Nagy, Peter D" uniqKey="Nagy P" first="Peter D" last="Nagy">Peter D. Nagy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, United States. Electronic address: pdnagy2@uky.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author></analytic><series><title level="j">Virology</title><idno type="eISSN">1096-0341</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphate (metabolism)</term><term>Glycolysis (MeSH)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors)</term><term>Mechanistic Target of Rapamycin Complex 1 (metabolism)</term><term>Morpholines (pharmacology)</term><term>RNA Replicase (metabolism)</term><term>RNA, Viral (biosynthesis)</term><term>Ribonucleotides (biosynthesis)</term><term>Saccharomyces cerevisiae (drug effects)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae (virology)</term><term>Saccharomyces cerevisiae Proteins (antagonists & inhibitors)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>Sirolimus (pharmacology)</term><term>Tobacco (drug effects)</term><term>Tobacco (metabolism)</term><term>Tobacco (virology)</term><term>Tombusvirus (genetics)</term><term>Tombusvirus (physiology)</term><term>Transcription Factors (antagonists & inhibitors)</term><term>Transcription Factors (metabolism)</term><term>Virus Replication (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (biosynthèse)</term><term>Adénosine triphosphate (métabolisme)</term><term>Complexe-1 cible mécanistique de la rapamycine (antagonistes et inhibiteurs)</term><term>Complexe-1 cible mécanistique de la rapamycine (métabolisme)</term><term>Facteurs de transcription (antagonistes et inhibiteurs)</term><term>Facteurs de transcription (métabolisme)</term><term>Glycolyse (MeSH)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Morpholines (pharmacologie)</term><term>Protéines de Saccharomyces cerevisiae (antagonistes et inhibiteurs)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>RNA replicase (métabolisme)</term><term>Ribonucléotides (biosynthèse)</term><term>Réplication virale (MeSH)</term><term>Saccharomyces cerevisiae (effets des médicaments et des substances chimiques)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Saccharomyces cerevisiae (virologie)</term><term>Sirolimus (pharmacologie)</term><term>Tabac (effets des médicaments et des substances chimiques)</term><term>Tabac (métabolisme)</term><term>Tabac (virologie)</term><term>Tombusvirus (génétique)</term><term>Tombusvirus (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Mechanistic Target of Rapamycin Complex 1</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>RNA, Viral</term><term>Ribonucleotides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Triphosphate</term><term>Mechanistic Target of Rapamycin Complex 1</term><term>RNA Replicase</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Morpholines</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Facteurs de transcription</term><term>Protéines de Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>ARN viral</term><term>Ribonucléotides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Saccharomyces cerevisiae</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Saccharomyces cerevisiae</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Saccharomyces cerevisiae</term><term>Tombusvirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Saccharomyces cerevisiae</term><term>Tombusvirus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term><term>Tobacco</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine triphosphate</term><term>Complexe-1 cible mécanistique de la rapamycine</term><term>Facteurs de transcription</term><term>Protéines de Saccharomyces cerevisiae</term><term>RNA replicase</term><term>Saccharomyces cerevisiae</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Morpholines</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Tombusvirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Tombusvirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Saccharomyces cerevisiae</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Saccharomyces cerevisiae</term><term>Tobacco</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Glycolysis</term><term>Host-Pathogen Interactions</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Glycolyse</term><term>Interactions hôte-pathogène</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Similar to other (+)RNA viruses, tomato bushy stunt virus (TBSV) utilizes metabolites, lipids, membranes, and co-opted host factors during replication. The coordination of cell metabolism and growth with environmental cues is performed by the target of rapamycin (TOR) kinase in eukaryotic cells. In this paper, we find that TBSV replication partially inhibits TOR activity, likely due to recruitment of glycolytic enzymes to the viral replication compartment, which results in reduced ATP levels in the cytosol. Complete inhibition of TOR activity with rapamycin in yeast or AZD8055 inhibitor in plants reduces tombusvirus replication. We find that high glucose concentration, which stimulates TOR activity, enhanced tombusvirus replication in yeast. Depletion of yeast Sch9 or plant S6K1 kinase, a downstream effector of TOR, also inhibited tombusvirus replication in yeast and plant or the assembly of the viral replicase in vitro. Altogether, the TOR pathway is crucial for TBSV to replicate efficiently in hosts.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29734044</PMID><DateCompleted><Year>2018</Year><Month>06</Month><Day>13</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0341</ISSN><JournalIssue CitedMedium="Internet"><Volume>519</Volume><PubDate><Year>2018</Year><Month>06</Month></PubDate></JournalIssue><Title>Virology</Title><ISOAbbreviation>Virology</ISOAbbreviation></Journal><ArticleTitle>Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.</ArticleTitle><Pagination><MedlinePgn>207-222</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0042-6822(18)30128-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.virol.2018.04.010</ELocationID><Abstract><AbstractText>Similar to other (+)RNA viruses, tomato bushy stunt virus (TBSV) utilizes metabolites, lipids, membranes, and co-opted host factors during replication. The coordination of cell metabolism and growth with environmental cues is performed by the target of rapamycin (TOR) kinase in eukaryotic cells. In this paper, we find that TBSV replication partially inhibits TOR activity, likely due to recruitment of glycolytic enzymes to the viral replication compartment, which results in reduced ATP levels in the cytosol. Complete inhibition of TOR activity with rapamycin in yeast or AZD8055 inhibitor in plants reduces tombusvirus replication. We find that high glucose concentration, which stimulates TOR activity, enhanced tombusvirus replication in yeast. Depletion of yeast Sch9 or plant S6K1 kinase, a downstream effector of TOR, also inhibited tombusvirus replication in yeast and plant or the assembly of the viral replicase in vitro. Altogether, the TOR pathway is crucial for TBSV to replicate efficiently in hosts.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Inaba</LastName><ForeName>Jun-Ichi</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagy</LastName><ForeName>Peter D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, United States. Electronic address: pdnagy2@uky.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>05</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Virology</MedlineTA><NlmUniqueID>0110674</NlmUniqueID><ISSNLinking>0042-6822</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009025">Morpholines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012265">Ribonucleotides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>8L70Q75FXE</RegistryNumber><NameOfSubstance UI="D000255">Adenosine Triphosphate</NameOfSubstance></Chemical><Chemical><RegistryNumber>970JJ37FPW</RegistryNumber><NameOfSubstance UI="C546624">(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber><NameOfSubstance UI="D000076222">Mechanistic Target of Rapamycin Complex 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.7.48</RegistryNumber><NameOfSubstance UI="D012324">RNA Replicase</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000255" MajorTopicYN="N">Adenosine Triphosphate</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006019" MajorTopicYN="N">Glycolysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000076222" MajorTopicYN="N">Mechanistic Target of Rapamycin Complex 1</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009025" MajorTopicYN="N">Morpholines</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012324" MajorTopicYN="N">RNA Replicase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012265" MajorTopicYN="N">Ribonucleotides</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017864" MajorTopicYN="N">Tombusvirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014779" MajorTopicYN="Y">Virus Replication</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Glycolysis</Keyword><Keyword MajorTopicYN="Y">In vitro</Keyword><Keyword MajorTopicYN="Y">Plant</Keyword><Keyword MajorTopicYN="Y">Replication</Keyword><Keyword MajorTopicYN="Y">Ribonucleotide synthesis</Keyword><Keyword MajorTopicYN="Y">TBSV</Keyword><Keyword MajorTopicYN="Y">TOR kinase</Keyword><Keyword MajorTopicYN="Y">Tomato bushy stunt virus</Keyword><Keyword MajorTopicYN="Y">Virus-host interaction</Keyword><Keyword MajorTopicYN="Y">Yeast</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>02</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>04</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>6</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>5</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29734044</ArticleId><ArticleId IdType="pii">S0042-6822(18)30128-4</ArticleId><ArticleId IdType="doi">10.1016/j.virol.2018.04.010</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Kentucky</li></region></list><tree><country name="États-Unis"><region name="Kentucky"><name sortKey="Inaba, Jun Ichi" sort="Inaba, Jun Ichi" uniqKey="Inaba J" first="Jun-Ichi" last="Inaba">Jun-Ichi Inaba</name></region><name sortKey="Nagy, Peter D" sort="Nagy, Peter D" uniqKey="Nagy P" first="Peter D" last="Nagy">Peter D. Nagy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000438 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000438 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29734044
|texte= Tombusvirus RNA replication depends on the TOR pathway in yeast and plants.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29734044" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |